Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 49, Pages 7699-7702Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc03157a
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Funding
- National Natural Science Foundation of P. R. China [21272192, 21472154, 21572184]
- Program for Changjiang Scholars and Innovative Research Team of P. R. China (PCSIRT)
- National Thousand Talents Program of P. R. China
- Fundamental Research Funds for the Central Universities [20720160027]
- 985 Program of the Chemistry and Chemical Engineering disciplines of Xiamen University
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A strategy for dual transition metal catalysis and organocatalysis is reported via the in situ disintegration of a single rhodium complex. The hereby generated chiral Lewis acid and L-beta-phenylalanine synergistically catalyze the Michael addition of alpha, alpha-disubstituted aldehydes to alpha, beta-unsaturated 2-acyl imidazoles under the formation of vicinal quaternary/tertiary stereocenters. Conveniently, the chiral-at-metal rhodium catalyst can be synthesized in just two steps starting from rhodium trichloride without the need for any chromatography.
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