Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 13, Pages 2736-2739Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc09918h
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Funding
- NSFC [21125209, 21332003]
- MOST [2011CB808600]
- STCSM [15ZR1411000]
- State Key Laboratory of Advanced Technology for Materials Synthesis and Processing [2015-KF-11]
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The first example of chiral secondary amine and iridium(I) co-catalyzed enantioselective three-component reaction of aryldiazoacetates, indoles and enals was rationally designed and developed to afford 3-substituted indole derivatives in good yields and with moderate diastereoselectivity as well as excellent enantioselectivity. This reaction is proposed to proceed through the enantioselective trapping of iridium(I)-associated zwitterionic intermediates via selective 1,4-addtition to the chiral amine activated enals.
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