Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 69, Pages 10525-10528Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc04127b
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Funding
- MRSEC of the National Science Foundation [DMR 1121053]
- PREM of the National Science Foundation [DMR-1205194]
- NIH [U01 (HL099773-1)]
- Garland Initiative
- Institute for Collaborative Biotechnologies from U.S. Army Research Office [W911NF-09-0001]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [U01HL099773] Funding Source: NIH RePORTER
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We present a one-photon visible light-responsive micellar system for efficient, on-demand delivery of small molecules. Release is mediated by a novel class of photochromic material - donor-acceptor Stenhouse adducts (DASAs). We demonstrate controlled delivery of small molecules such as the chemotherapeutic agent (paclitaxel) to human breast cancer cells triggered by micellar switching with low intensity, visible light.
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