4.7 Article

Novel BODIPY-based Ru(II) and Ir(III) metalla-rectangles: cellular localization of compounds and their antiproliferative activities

Journal

CHEMICAL COMMUNICATIONS
Volume 52, Issue 23, Pages 4274-4277

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc00046k

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Funding

  1. Post-Doctoral Research Program through Incheon National University (INU), Incheon, Republic of Korea

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The first examples of Ru(II) and Ir(III) metalla-rectangles [1](4+)-[4](4+) containing a BODIPY-based linker are reported; some of these compounds exhibited highly selective anticancer activity and interact strongly with DNA as well as protein. The characteristic green fluorescence of a BODIPY ligand and associated aggregation-induced emission (AIE) permitted visualization of compounds inside the cells using confocal microscopy.

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