Journal
CHEMICAL COMMUNICATIONS
Volume 52, Issue 30, Pages 5254-5257Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc01195k
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Funding
- National Science Foundation [CHE-1412295]
- Center for Applied Plant Sciences (CAPS) of the Ohio State University
- Boston University
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The self-assembly of 5-fluorouracil dilysine conjugates into self-supporting hydrogels, comprised of entangled nanofibers or rigid nanotubes with diameters of 10 and 16 nm, respectively, is reported. The rate of release of 5-Fu from the conjugates was highly dependent on concentration in solution, whereas, release from the fully formed hydrogels was significantly slower. The 5-Fu conjugate also exhibited promising in vitro cytotoxicity against human tumor cell lines A549, H460 and H23.
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