Enantioselective synthesis of quaternary alpha-aminophosphonates by Pd-catalyzed arylation of cyclic alpha-ketiminophosphonates with arylboronic acids

A highly enantioselective addition of arylboronic acids to cyclic alpha-ketiminophosphonates is reported using a chiral palladium phos-phinooxazoline catalyst, providing an efficient and facile route to quaternary alpha-aminophosphonates in high yields and up to 99.9% enantioselectivity.