Journal
JOURNAL OF CHEMICAL PHYSICS
Volume 152, Issue 14, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/5.0002044
Keywords
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Funding
- University of Ottawa [RGPIN/046434-2013]
- Natural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN/046434-2013]
- Chinese Scholarship Council
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Both the translational diffusion coefficient D and the electrophoretic mobility mu of a short rod-like molecule (such as dsDNA) that is being pulled toward a nanopore by an electric field should depend on its orientation. Since a charged rod-like molecule tends to orient in the presence of an inhomogeneous electric field, D and mu will change as the molecule approaches the nanopore, and this will impact the capture process. We present a simplified study of this problem using theoretical arguments and Langevin dynamics simulations. In particular, we introduce a new orientational capture radius, which we compare to the capture radius for the equivalent point-like particle, and we discuss the different physical regimes of orientation during capture and the impact of initial orientations on the capture time.
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