Journal
CHEMICAL BIOLOGY & DRUG DESIGN
Volume 88, Issue 6, Pages 899-904Publisher
WILEY
DOI: 10.1111/cbdd.12823
Keywords
characterization; indolizine analogues; larvicidal activity; synthesis
Funding
- Sahyadri Science College, Shimoga
- National Research Foundation, South Africa [96807]
- Durban University of Technology
- Korea Agency for Infrastructure Technology Advancement (KAIA) [96807] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Greener synthesis of a series of novel indolizine analogues have been achieved by the cyclization of aromatic cycloimmonium ylides with electron-deficient alkynes in the presence of water as the base and solvent at 80 degrees C. Yield of the title compounds was good and reactions performed were eco-friendly. The structures of these newly synthesized compounds have been confirmed by spectroscopic techniques such as FTIR, NMR, LC-MS, and elemental analysis. Characterized title compounds were evaluated for larvicidal activity against Anopheles arabiensis by standard WHO larvicidal assay using Temefos as standard at 4g/mL. Title compounds 2e, 2f, and 2g emerged as promising larvicidal agents.
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