Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 24, Issue 10, Pages 5865-5877Publisher
WILEY
DOI: 10.1111/jcmm.15260
Keywords
exercise; gender; immune function; inflammation; microRNAs; myalgic encephalomyelitis; chronic fatigue syndrome; peripheral blood mononuclear cell
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Funding
- NIH [1R15NS087604-01A1, 1R21AI124187-01, 5R01NS090200-02, 5R01AR057853-04, UCV-2019270-001]
- Presidential Faculty Research and Development Grant from Nova Southeastern University
- CDMRP award [W81XWH-09-2-0071]
- Catalonia Association for Fibromyalgia, Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Environmental Sensitivities/Multiple Chemical Sensitivity (ACAF)
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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem illness characterized by medically unexplained debilitating fatigue with suggested altered immunological state. Our study aimed to explore peripheral blood mononuclear cells (PBMCs) for microRNAs (miRNAs) expression in ME/CFS subjects under an exercise challenge. The findings highlight the immune response and inflammation links to differential miRNA expression in ME/CFS. The present study is particularly important in being the first to uncover the differences that exist in miRNA expression patterns in males and females with ME/CFS in response to exercise. This provides new evidence for the understanding of differential miRNA expression patterns and post-exertional malaise in ME/CFS. We also report miRNA expression pattern differences associating with the nutritional status in individuals with ME/CFS, highlighting the effect of subjects' metabolic state on molecular changes to be considered in clinical research within the NINDS/CDC ME/CFS Common Data Elements. The identification of gender-based miRNAs importantly provides new insights into gender-specific ME/CFS susceptibility and demands exploration of sex-suited ME/CFS therapeutics.
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