Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 64, Issue 5, Pages 507-511Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c15-00805
Keywords
Atractylodes macrocephala; Compositae; sesquiterpenoid; anti-inflammatory activity; RAW264.7 cell
Funding
- Research Grants from Catholic University of Daegu
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Three new sesquiterpenoids, 13-hydroxyl-atractylenolide II (1), 4-ketone-atractylenolide III (2), and eudesm-4(15)-ene-7 beta,11-diol (3), along with eleven known compounds (4-14), were isolated from the rhizomes of Atractylodes macrocephala. The structures and relative configurations of 1-3 were determined by analysis of the spectroscopic data, and the absolute configurations of 1 and 2 were assigned by circular dichroism technique. The anti-inflammatory activities of these isolates were evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cells; compounds 4, 7, and 8 exhibited moderate efficacy with IC50 values of 48.6+/-0.5, 46.4+/-3.2, and 32.3+/-2.9 mu M, respectively.
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