Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 64, Issue 1, Pages 73-77Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c15-00686
Keywords
Cyperus rotundus; rotunduside G; rotunduside H; antidepressant
Funding
- National Natural Science Foundation of China [31400295]
- China Spark Program [2014GA780014]
- Science and Technology Planning Project of Guangdong Province [2014A020221057]
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Based on bioactive screening results, two new iridoid glycosides, named rotunduside G (1) and rotunduside H (2), were isolated from the rhizomes of Cyperus rotundus, together with four known ones, negundoside (3), nishindaside (4), isooleuropein (5) and neonuezhenide (6). Their structures were elucidated on the basis of spectroscopic methods and from literature values. In mice models of despair, 1 and 2 showed significant antidepressant activity.
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