Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 64, Issue 7, Pages 952-956Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c16-00180
Keywords
Oryza sativa; rice; specialized metabolite; anti-inflammatory; anti-oxidant
Funding
- Japan Science and Technology Agency (JST)
- Strategic International Collaborative Research Program (SICORP)
- Japan Advanced Plant Science Research Network
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Oryza sativa L. (rice) is an important staple crop across the world. In the previous study, we identified 36 specialized (secondary) metabolites including 28 flavonoids. In the present study, a metabolome analysis using liquid chromatography-mass spectrometry was conducted on the leaf, bran, and brown and polished rice grains to better understand the distribution of these metabolites. Principal component analysis using the metabolome data clearly characterized the accumulation patterns of the metabolites. Flavonoids, e.g., tricin, tricin 7-O-rutinoside, and tricin 7-O-beta-D-glucopyranoside, were mainly present in the leaf and bran but not in the polished grain. In addition, anti-inflammatory and anti-oxidant activity of the metabolites were assayed in vitro. Tricin 4'-O-(erythro-beta-guaiacylglyceryl)ether and isoscoparin 2 ''-O-(6 ''-(E)-feruloyl)glucopyranoside showed the strongest activity for inhibiting nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging, respectively.
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