Journal
JOURNAL OF BIOSCIENCES
Volume 45, Issue 1, Pages -Publisher
INDIAN ACAD SCIENCES
DOI: 10.1007/s12038-020-00045-2
Keywords
AZT; breast cancer; EMT; hTERT; TRAP assay
Categories
Funding
- Department of Science and Technology
- University Grants Commission of the Government of India
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Telomerase is a specialized enzyme which maintains telomere length at the extreme end of the chromosome. Over 90% of all cases of cancer show high expression of telomerase while in normal cells, its expression is extremely low or undetectable. Detection of telomerase activity in a wide range of breast cancer makes telomerase an interesting target for diagnosis and therapy. In this review, we have aimed to describe telomerase as a therapeutic and accurate diagnostic target in breast cancer. Telomerase performs many extracurricular activities apart from maintaining telomere length; here, we have also tried to address its role in epithelial-mesenchymal transition (EMT) of breast cancer progression.
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