Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 108, Issue 8, Pages 1688-1702Publisher
WILEY
DOI: 10.1002/jbm.a.36935
Keywords
bovine serum albumin nanoparticles (BSANPs); drug release kinetic; microemulsion; multifunctional drug delivery; paclitaxel
Funding
- Faculty of Pharmacy, Zanjan University of Medical Sciences [A-12-430-41]
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The present study aims to: (a) design the versatile microemulsions (MEs) system for drug delivery; (b) use the bovine serum albumin nanoparticles for MEs system development; (c) characterize the physicochemical properties, cytotoxicity, and biocompatibility of the modified MEs (MMEs) system; (d) load of paclitaxel (PTX) and folate conjugate of MEs system; and (e) assess the potential of anticancer activity of MEs system. The physicochemical possessions, in vitro and in vivo cytotoxicity, and stability of MMEs system were characterized. The results of our study show that the MEs system was stable, having narrow particle size distribution, nontoxic, biocompatible, and not active for leukocyte proliferation. So it can be concluded that the MMEs system as a promising candidate for a targeted multifunctional drug delivery system (PTX and folate) that is called a smart MEs system.
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