Journal
CHEMBIOCHEM
Volume 17, Issue 12, Pages 1138-1141Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201600052
Keywords
anticancer; DNA walker; DNAzyme; growth inhibition; oligonucleotides
Funding
- U.S. Office of Naval Research National Science Foundation
- National Institutes of Health [UL1TR000006]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1512537] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1437301, 1055866] Funding Source: National Science Foundation
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We demonstrate a DNAzyme-based walker system as a controlled oligonucleotide drug AS1411 release platform for breast cancer treatment. In this system, AS1411 strands are released from fuel strands as a walker moves along its carbon nanotube track. The release rate and amount of anticancer oligonucleotides are controlled by the walker operation. With a walker system embedded within the collagen extracellular matrix, we show that this drug release system can be used for in situ cancer cell growth inhibition.
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