Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 31, Issue 9, Pages 1179-1198Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2020.1747184
Keywords
Polyvinyl alcohol; type II collagen; hydrogels; articular cartilage tissue engineering
Funding
- Natural Science Foundation of China [11632013, 11572213, 11502158]
- International Cooperation Project Foundation of Shanxi Province [201803D421060]
- Natural Science Foundation for Young Scientist of Shanxi Province, China [201901D111078, 201801D221439]
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Type II collagen (Col-II) is one of the important organic components of the cartilage extracellular matrix (ECM). Such natural material is known for its good biocompatibility, but it could not provide a good supporting environment for seed cells due to its rapid degradation and poor strength. In the present work, different contents of Col-II were incorporated into porous polyvinyl alcohol (PVA) to fabricate porous PVA/Col-II composite hydrogels for cartilage tissue engineering. The results illustrate that, after incorporation of Col-II, the elasticity modulus of the composite hydrogels firstly increases, and then decreases (under moisture state). The elasticity modulus of PVA/Col-II (at the ratio of 1:1) hydrogels reaches 11 +/- 1.7 KPa, about two-fold higher than pure PVA hydrogels (4.9 +/- 0.6 KPa). Meanwhile, all hydrogels exhibit relatively high water content (> 95%) and porosity (> 75%). The degradation analysis indicates that Col-II incorporation induce a high degradation ratio of the composite hydrogels. Cell culture results show PVA/Col-II hydrogels have no negative effects on cells viability and proliferation. The PVA/Col-II hydrogels may possess a potential application in the field of articular cartilage tissue engineering and regeneration.
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