Journal
JOURNAL OF BIOMATERIALS APPLICATIONS
Volume 35, Issue 2, Pages 158-168Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328220926655
Keywords
Cardiovascular stent materials; biodegradable magnesium; corrosion resistance; pro-endothelialization; surface modification
Funding
- Key Projects of the Joint Fund of the National Natural Science Foundation of China [U1804251]
- National Key Research and Development Program of China [2018YFC1106703, 2017YFB0702500, 2016YFC1102403]
- National Natural Science Foundation of China [NSFC51671175]
- Top Doctor Program of Zhengzhou University [32210475]
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Magnesium alloy is generally accepted as a potential cardiovascular stent material due to its good mechanical properties, biocompatibility, and biodegradability, and has become one of the research hotspots in this field. However, too fast degradation rate and delayed surface endothelialization have been the bottleneck of further application of magnesium alloy stent. In this study, we selected Mg-Zn-Y-Nd, a kind of biodegradable magnesium alloy for cardiovascular stent, and passivated its surface by alkali heat treatment and silane treatment to improve the corrosion resistance, subsequently conjugated Arg-Glu-Asp-Val (REDV) peptide and anti-CD34 to promote endothelial cells adhesion and capture endothelial progenitor cells respectively, further improving surface endothelialization. In addition, the heparin was also immobilized to the Mg-Zn-Y-Nd surface for the consideration of anti-coagulation and anti-inflammation. Systematic material characterization and biological evaluation show that we have successfully developed this composite surface on Mg-Zn-Y-Nd alloy, and achieved multiple functions such as corrosion resistance, promoting endothelialization, and inhibiting platelet/macrophage adhesion.
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