Journal
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
Volume 27, Issue 6, Pages 509-515Publisher
JAPAN ATHEROSCLEROSIS SOC
DOI: 10.5551/jat.50930
Keywords
Diabetes mellitus; Aortic dilatation; Aortic calcification; Coronary artery disease; Atherosclerosis
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Funding
- Aichi Kidney Foundation
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) [19K17591]
- Japanese Society for the Promotion of Science (JSPA)
- Grants-in-Aid for Scientific Research [19K17591] Funding Source: KAKEN
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Aim: An inverse association between diabetes mellitus (DM) and aortic dilatation has recently been reported. However, little is known about the association between DM and the progression of aortic dilatation/calcification as atherosclerosis progresses. Methods: We identified 216 patients who had undergone percutaneous coronary intervention (PCI) and abdominal computed tomography (CT) during the PCI and follow-up phases. The patients were classified into two groups: those with DM (DM+ group; n=107) and those without DM (DM- group; n=109). The infrarenal aortic diameter and aortic calcification index (ACI) were measured, and annual changes were calculated using measurement results obtained during the PCI and follow-up phases. Results: Infrarenal aortic diameters were significantly shorter in the DM+ group than in the DM- group during the PCI phase, and no significant ACI differences were observed between the DM+ and DM- groups. The median duration between the PCI and follow-up phase CT was 3.0 years. The growth rate of the infrarenal aortic dilatation from the PCI phase in the DM+ group was similar to that in the DM- group. Annual ACI changes were significantly larger in the DM+ group than in the DM- group. Multivariate logistic regression analysis indicated that the prevalence of DM was an independent predictor of rapid aortic calcification progression (odds ratio: 2.51; 95% confidence interval: 1.23-5.14; p= 0.01). Conclusion: Our findings suggest that DM negatively affects aortic dilatation during an earlier phase of atherosderosis progression and positively affects the progression of aortic calcification in a later phase.
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