Journal
CHEMBIOCHEM
Volume 17, Issue 17, Pages 1585-1588Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201600261
Keywords
anti-malaria; biosynthesis; jogyamycin; natural products; pactamycin; Streptomyces
Funding
- OSU College of Pharmacy
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Pactamycin is a bacteria-derived aminocyclitol antibiotic with a wide-range of biological activity. Its chemical structure and potent biological activities have made it an interesting lead compound for drug discovery and development. Despite its unusual chemical structure, many aspects of its formation in nature remain elusive. Using a combination of genetic inactivation and metabolic analysis, we investigated the tailoring processes of pactamycin biosynthesis in Streptomyces pactum. The results provide insights into the sequence of events during the tailoring steps of pactamycin biosynthesis and explain the unusual production of various pactamycin analogues by S.pactum mutants. We also identified two new pactamycin analogues that have better selectivity indexes than pactamycin against malarial parasites.
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