Journal
CHEMBIOCHEM
Volume 17, Issue 12, Pages 1052-1062Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201600014
Keywords
AuNPs; biomedical applications; DNA aptamers; gold nanoparticles
Funding
- Ministry of Science and Technology of Taiwan (MOST) [NSC 103-2923-M-002-002-MY3, 104-2923-M-002-006-MY3, 104-2113-M-002-008-MY3]
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Gold nanoparticles (AuNPs) are useful for diagnostic and biomedical applications, mainly because of their ease in preparation and conjugation, biocompatibility, and size-dependent optical properties. However, bare AuNPs do not possess specificity for targets. AuNPs conjugated with DNA aptamers offer specificity for various analytes, such as proteins and small molecules/ions. Although DNA aptamers themselves have therapeutic and target-recognizing properties, they are susceptible to degradation in vivo. When DNA aptamers are conjugated to AuNPs, their stability and cell uptake efficiency both increase, making aptamer-AuNPs suitable for biomedical applications. Additionally, drugs can be efficiently conjugated with DNA aptamer-AuNPs to further enhance their therapeutic efficiency. This review focuses on the applications of DNA aptamer-based AuNPs in several biomedical areas, including anticoagulation, anticancer, antibacterial, and antiviral applications.
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