Journal
JOURNAL OF APPLIED BIOMEDICINE
Volume 18, Issue 2-3, Pages 54-60Publisher
UNIV SOUTH BOHEMIA
DOI: 10.32725/jab.2020.007
Keywords
Adipocyte-fatty acid binding protein; Adiponectin; Gestational diabetes; Insulin resistance; Type 2 diabetes; Wnt1 inducible signaling pathway protein-1
Funding
- Czech health research council [AZV NV18-01-00139]
- University Hospital Olomouc - MH CZ DRO (FNOl) [00098892]
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Backgrounds: Adiponectin, adipocyte-fatty acid binding protein (A-FABP), and Wnt1 inducible signaling pathway protein-1 (WISP-1) are adipokines doselyassodated with insulin resistance. The aim of the study was to compare their levels in women with gestational diabetes (GDM), type 2 diabetes mellitus (T2DM) and healthy controls and determine their relation to metabolic parameters. Methods: Women with GDM, T2DM and healthy women were induded in this cross-sectional study. In addition to adipokines, anthropometric, lipid parameters, markers of insulin resistance and glucose control were assessed in all participants. Results: Compared to healthy controls (n = 35) significantly lower levels of adiponectin were detected in women with GDM (n = 50), whereas in women with T2DM (n = 50) higher levels of A-FABP and WISP-1 and lower levels of adiponectin were found. Women with T2DM had also lower levels of adiponectin and higher levels of A-FABP compared to women with GDM. A-FABP and adiponectin were independently associated with levels of triglycerides, HDL-cholesterol and C-peptide insulin resistance index. WISP-1 correlated only with waist circumference. Conclusions: Adverse adipokines production reflecting dysfunctional fat tissue is less presented in women with GDM than in women with T2DM, but more expressed compared to healthy women.
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