Journal
CHEMBIOCHEM
Volume 18, Issue 1, Pages 119-125Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201600422
Keywords
cellular uptake; dendrimers; drug delivery; guanidinium-rich transporters; guanidinoglycosides; PAMAM
Funding
- Politecnico di Milano
- Fulbright Program
Ask authors/readers for more resources
We present the synthesis of polymeric amino-and guanidinoglycosides prepared by tethering neomycin and guanidinoneomycin to PAMAM dendrimers of generations 2 and 4. The ability of these conjugates to promote cellular uptake of high-molecular-weight cargo is discussed, together with their cytotoxicity and mechanisms of entry. We demonstrate that the presence of multiple guanidinoneomycin carriers on the PAMAM surface plays an important role in promoting cellular uptake of the dendrimers, maintaining the heparan sulfate specificity and negligible cytotoxicity typical of monomeric guanidinoglycoside molecular transporters.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available