Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 68, Issue 23, Pages 6420-6429Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.0c01315
Keywords
dendrimer-like glucan; resveratrol; nanoparticulate; solid dispersion; characterization
Funding
- National Key R&D Program of China [2018YFC1602101, 2017YFC1601002]
- National Natural Science Foundation of China [31972029]
- China Postdoctoral Science Foundation [2019M661862]
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In this study, sugary maize dendrimer-like glucan (SMDG) was used as a delivery carrier for improving the bioavailability of resveratrol (RES). After optimization, the solubility of RES in RES-SMDG markedly increased to approximately 9.1 times that of the raw RES solution. The structural characterizations of the RES-SMDG formulation showed crystal RES was entrapped in the SMDG matrix for the amorphous state due to the strong intermolecular hydrogen bonds between the -OH of RES and glucan chains. In this case, antioxidant activity of RES-SMDG was markedly higher than that of the raw RES solution. In the Caco-2 cell model, the P-app value of RES in the RES-SMDG group was slightly higher than those of common permeable compounds, while the cellular uptake was significantly improved. RES-SMDG also exhibited protective effects against cellular damage under oxidative stress. The results indicated that SMDG is an attractive carrier to encapsulate and protect hydrophilic bioactive ingredients.
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