Journal
ISRAEL JOURNAL OF CHEMISTRY
Volume 60, Issue 3-4, Pages 340-350Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ijch.201900176
Keywords
cross-coupling; process development; palladium; rhodium; copper
Categories
Ask authors/readers for more resources
A perspective of our work on the development of practical metal-mediated carbon-carbon and carbon-heteroatom bond forming processes within a modern drug portfolio is presented. The case studies selected from our laboratories highlight the synthetic challenges and opportunities presented by pharmaceutically relevant scaffolds. In many cases, the target structures challenged available synthetic methods and inspired the invention of enabling technology to accelerate drug development. Additionally, considerations for running metal-mediated processes on large scale are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available