Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 70, Issue 10, Pages 730-741Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2020.1760274
Keywords
Chitosan; hydrogel; methacrylation; polysaccharide; tissue engineering
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Funding
- Tehran University of Medical Sciences [27551]
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A novel method for synthesizing photocrosslinkable chitosan hydrogel was introduced in this study. Methacrylated chitosan obtained under controlled conditions and using EDC/NHS showed significant coupling efficiency and gel formation capacity, with interconnected pores and swelling ratios, providing new aspects for developing novel biomaterials in cell-based therapies.
In this study, we introduced a novel and modified method to synthesize photocrosslinkable chitosan hydrogel. Three methacrylated samples under two concentrations of methacrylic anhydride and using EDC/NHS as a crosslinker were prepared. Methacrylated chitosan obtained under controlled conditions and using EDC/NHS had significant coupling efficiency and capacity of gel formation compared to other samples. Diluted culture media provided a favorable solubility condition for methacrylated chitosan and could be tolerated by cells during gelation time. The hydrogels included interconnected pores ranging 100-300 mu m and swelling ratios of 40-400%. The results opened the new aspects for developing novel biomaterials in cell-based therapies. [GRAPHICS] .
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