Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume 57, Issue 1, Pages 264-276Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2020.5055
Keywords
microRNA-508-3p; proliferation; metastasis; CCNA2; MMP7; ovarian carcinoma
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Funding
- National Natural Science Foundation of China [81772790, 81602292, 81472761]
- Science & Technology Foundation for Selected Overseas Chinese Scholars, Bureau of Personnel of China, Tianjin [2016017]
- Tianjin Medical University General Hospital Grant [ZYYFY2014004]
- Postgraduate Innovation Fund of 13th Five-year comprehensive investment, Tianjin Medical University [YJSCX201812]
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Ovarian cancer is the most lethal gynecological tumor, and the 5-year survival rate is only similar to 40%. The poor survival rate is due to cancer diagnosis at an advanced stage, when the tumor has metastasized. A better understanding of the molecular pathogenesis of tumor growth and metastasis is needed to improve patient prognosis. MicroRNAs (miRs) regulate carcinogenesis and development of cancers. However, the role of miR-508-3p in ovarian cancer remains largely unknown. Thus, the present study aimed to investigate the possible functions of miR-508-3p in the modulation of development of ovarian cancer. The results of the present study demonstrated that miR-508-3p mimics inhibited ovarian cancer cell proliferation, migration and invasion. Reporter gene assay results demonstrated that miR-508-3p suppressed cancer cell proliferation by directly targeting the 3 '-untranslated region (UTR) of cyclin A2 (CCNA2) and suppressed migration and invasion by directly targeting the 3 '-UTR of matrix metallo-proteinase 7 (MMP7). In addition, high CCNA2 and MMP7 expression levels were associated with low miR-508-3p expression in ovarian cancer tissues. Furthermore, miR-508-3p and CCNA2 were independent predictors for overall survival in patients with ovarian cancer. To the best of our knowledge, this is the first study to demonstrated that miR-508-3p suppressed ovarian cancer development by directly targetingCCNA2andMMP7. The results of this study suggested the potential value of miR-508-3p and CCNA2 as prognostic indicators and therapeutics for ovarian cancer.
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