4.7 Article

Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices

Journal

INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 15, Issue -, Pages 3649-3667

Publisher

DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S245300

Keywords

glial scar; neuroinflammation; nanoparticles; brain implants

Funding

  1. Deutsche Forschungsgemeinschaft (DFG) [RTG2154]
  2. DFG [SFB877, 125440785]

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Introduction: The polyphenolic spice and food coloring ingredient curcumin has beneficial effects in a broad variety of inflammatory diseases. Amongst them, curcumin has been shown to attenuate microglia reaction and prevent from glial scar formation in spinal cord and brain injuries. Methods: We developed a protocol for the efficient encapsulation of curcumin as a model for anti-inflammatory drugs yielding long-term stable, non-toxic liposomes with favorable physicochemical properties. Subsequently, we evaluate the effects of liposomal curcumin in experimental models for neuroinflammation and reactive astrogliosis. Results: We could show that liposomal curcumin can efficiently reduce the reactivity of human microglia and astrocytes and preserve tissue integrity of murine organotypic cortex slices. Discussion and Perspective: In perspective, we want to administer this curcumin formulation in brain implant coatings to prevent neuroinflammation and glial scar formation as foreign body responses of the brain towards implanted materials.

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