Journal
CEREBRAL CORTEX
Volume 26, Issue 11, Pages 4148-4159Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhw238
Keywords
angular gyrus; dynamic networks; flexibility; language; language comprehension; lateralization; modularity; networks
Categories
Funding
- Rachleff Scholars Program of the University of Pennsylvania
- NSF award [BCS-1430087]
- Psychology Graduate Group of the University of Pennsylvania
- NICHD [K99/R00, HD057522]
- John D. and Catherine T. MacArthur Foundation
- Alfred P. Sloan Foundation
- Army Research Laboratory from the U.S. Army Research Office [W911NF-10-2-0022]
- U.S. Army Research Office [W911NF-14-1-0679]
- National Science Foundation [BCS-1430087, BCS-1441502]
- Division Of Behavioral and Cognitive Sci
- Direct For Social, Behav & Economic Scie [1430087] Funding Source: National Science Foundation
Ask authors/readers for more resources
During linguistic processing, a set of brain regions on the lateral surfaces of the left frontal, temporal, and parietal cortices exhibit robust responses. These areas display highly correlated activity while a subject rests or performs a naturalistic language comprehension task, suggesting that they form an integrated functional system. Evidence suggests that this system is spatially and functionally distinct from other systems that support high-level cognition in humans. Yet, how different regions within this system might be recruited dynamically during task performance is not well understood. Here we use network methods, applied to fMRI data collected from 22 human subjects performing a language comprehension task, to reveal the dynamic nature of the language system. We observe the presence of a stable core of brain regions, predominantly located in the left hemisphere, that consistently coactivate with one another. We also observe the presence of a more flexible periphery of brain regions, predominantly located in the right hemisphere, that coactivate with different regions at different times. However, the language functional ROIs in the angular gyrus and the anterior temporal lobe were notable exceptions to this trend. By highlighting the temporal dimension of language processing, these results suggest a trade-off between a region's specialization and its capacity for flexible network reconfiguration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available