Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/ijms21061931
Keywords
glioblastoma; astrocytoma; extracellular vesicles; exosomes; imaging flow cytometry; biomarker
Funding
- Anni Hofmann Stiftung
- Deutsche Forschungsgemeinschaft
- Johannes-Bauer Stiftung
- National Cancer Institute [P01CA069246]
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Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs, that results in compromised analytical sensitivity. Here we identified fatty acid synthase (FASN), a key lipogenic enzyme which is highly expressed in malignant glioma cells, to be elevated in CD63- and CD81-positive EVs in glioma patient plasma samples, opening vital opportunities to sort brain tumor-specific EVs.
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