Related references
Note: Only part of the references are listed.Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and -independent effects by CDK6-specific PROTACs
Marco De Dominici et al.
BLOOD (2020)
Dual FLT3 inhibitors: Against the drug resistance of acute myeloid leukemia in recent decade
Ting Yuan et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
CDK6 coordinates JAK2V617F mutant MPN via NF-κB and apoptotic networks
Iris Z. Uras et al.
BLOOD (2019)
Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML
Matthias Brand et al.
CELL CHEMICAL BIOLOGY (2019)
Novel therapy in Acute myeloid leukemia (AML): moving toward targeted approaches
Eric S. Winer et al.
THERAPEUTIC ADVANCES IN HEMATOLOGY (2019)
CDK6 Antagonizes p53-Induced Responses during Tumorigenesis
Florian Bellutti et al.
CANCER DISCOVERY (2018)
CDK4/6 Inhibition in Cancer: Beyond Cell Cycle Arrest
Shom Goel et al.
TRENDS IN CELL BIOLOGY (2018)
The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation
Natalia Martinez-Soria et al.
CANCER CELL (2018)
Therapeutic Vulnerabilities in FLT3-Mutant AML Unmasked by Palbociclib
Iris Z. Uras et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Phase I Study of Palbociclib Alone and in Combination in Patients with Relapsed and Refractory (R/R) Leukemias
Tapan M. Kadia et al.
BLOOD (2018)
Advances in targeted therapy for acute myeloid leukaemia
Sabine Kayser et al.
BRITISH JOURNAL OF HAEMATOLOGY (2018)
Management of adverse events during cyclin-dependent kinase 4/6 (CDK4/6) inhibitor-based treatment in breast cancer
Marc Thill et al.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2018)
Cdk6 contributes to cytoskeletal stability in erythroid cells
Iris Z. Uras et al.
HAEMATOLOGICA (2017)
FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27Kip1 in acute myeloid leukemia
Ines Peschel et al.
HAEMATOLOGICA (2017)
p27 in FLT3-driven acute myeloid leukemia: many roads lead to ruin
Iris Z. Uras et al.
HAEMATOLOGICA (2017)
MONARCH 3: Abemaciclib As Initial Therapy for Advanced Breast Cancer
Matthew P. Goetz et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Cdk6 contributes to cytoskeletal stability in erythroid cells
Iris Z. Uras et al.
HAEMATOLOGICA (2017)
FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27Kip1 in acute myeloid leukemia
Ines Peschel et al.
HAEMATOLOGICA (2017)
p27 in FLT3-driven acute myeloid leukemia: many roads lead to ruin
Iris Z. Uras et al.
HAEMATOLOGICA (2017)
System modeling reveals the molecular mechanisms of HSC cell cycle alteration mediated by Maff and Egr3 under leukemia
Rudong Li et al.
BMC SYSTEMS BIOLOGY (2017)
MONARCH 1, A Phase II Study of Abemaciclib, a CDK4 and CDK6 Inhibitor, as a Single Agent, in Patients with Refractory HR+/HER2- Metastatic Breast Cancer
Maura N. Dickler et al.
CLINICAL CANCER RESEARCH (2017)
A Phase I Study of the CDK4/6 Inhibitor Ribociclib (LEE011) in Pediatric Patients with Malignant Rhabdoid Tumors, Neuroblastoma, and Other Solid Tumors
Birgit Geoerger et al.
CLINICAL CANCER RESEARCH (2017)
Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression
Ashleigh R. Poh et al.
CANCER CELL (2017)
Loss of quiescence and self-renewal capacity of hematopoietic stem cell in an in vitro leukemic niche
Natalia-Del Pilar Vanegas et al.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2017)
Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6
Iris Z. Uras et al.
BLOOD (2016)
CDKIs p18INK4c and p57Kip2 are involved in quiescence of CML leukemic stem cells after treatment with TKI
Dafne Moreno-Lorenzana et al.
CELL CYCLE (2016)
Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer
G. N. Hortobagyi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Palbociclib and Letrozole in Advanced Breast Cancer
Richard S. Finn et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors
Amita Patnaik et al.
CANCER DISCOVERY (2016)
An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia
Sophie Lopez et al.
ONCOTARGET (2016)
Progression-Free Survival Among Patients With Well-Differentiated or Dedifferentiated Liposarcoma Treated With CDK4 Inhibitor Palbociclib A Phase 2 Clinical Trial
Mark A. Dickson et al.
JAMA ONCOLOGY (2016)
CDK4/6 Inhibitor Palbociclib for Treatment of KMT2A-Rearranged Acute Myeloid Leukemia: Interim Analysis of the AMLSG 23-14 Trial
Stefan Froehling et al.
BLOOD (2016)
Leukemic marrow infiltration reveals a novel role for Egr3 as a potent inhibitor of normal hematopoietic stem cell proliferation
Hui Cheng et al.
BLOOD (2015)
CDK4/6 Inhibitor PD 0332991 Sensitizes Acute Myeloid Leukemia to Cytarabine-Mediated Cytotoxicity
Chenyi Yang et al.
CANCER RESEARCH (2015)
CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells
Elisa Laurenti et al.
CELL STEM CELL (2015)
Age-Associated Methylation Suppresses SPRY1, Leading to a Failure of Re-quiescence and Loss of the Reserve Stem Cell Pool in Elderly Muscle
Anne Bigot et al.
CELL REPORTS (2015)
Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53
Kristina Kirschner et al.
PLOS GENETICS (2015)
CDK6 as a key regulator of hematopoietic and leukemic stem cell activation
Ruth Scheicher et al.
BLOOD (2015)
Epigenetic alterations in acute myeloid leukemias
Parinaz Mehdipour et al.
FEBS JOURNAL (2015)
AMG 925 Is a Dual FLT3/CDK4 Inhibitor with the Potential to Overcome FLT3 Inhibitor Resistance in Acute Myeloid Leukemia
Cong Li et al.
MOLECULAR CANCER THERAPEUTICS (2015)
The Orphan Nuclear Receptor NR4A1 Specifies a Distinct Subpopulation of Quiescent Myeloid-Biased Long-Term HSCs
Ruben H. Land et al.
STEM CELLS (2015)
Targeting cell cycle regulators in hematologic malignancies
Eiman Aleem et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2015)
Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice
Angela Stoddart et al.
BLOOD (2014)
Requirement for CDK6 in MLL-rearranged acute myeloid leukemia
Theresa Placke et al.
BLOOD (2014)
MLL fusion-driven activation of CDK6 potentiates proliferation in MLL-rearranged infant ALL
Marieke H. van der Linden et al.
CELL CYCLE (2014)
Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity
Prabhakara R. Nagareddy et al.
CELL METABOLISM (2014)
Cytotoxic CD8+ T Cells Stimulate Hematopoietic Progenitors by Promoting Cytokine Release from Bone Marrow Mesenchymal Stromal Cells
Christian M. Schuerch et al.
CELL STEM CELL (2014)
Role of activating transcription factor 3 protein ATF3 in necrosis and apoptosis induced by 5-fluoro-20-deoxyuridine
Akira Sato et al.
FEBS JOURNAL (2014)
Association of the type of 5q loss with complex karyotype, clonal evolution, TP53 mutation status, and prognosis in acute myeloid leukemia and myelodysplastic syndrome
Sarah Volkert et al.
GENES CHROMOSOMES & CANCER (2014)
Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3
Zhihong Li et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
FLT3 and CDK4/6 inhibitors: Signaling mechanisms and tumor burden in subcutaneous and orthotopic mouse models of acute myeloid leukemia
Yaping Zhang et al.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2014)
Expression of Kruppel-Like Factor 6, KLF6, in Rat Pituitary Stem/Progenitor Cells and Its Regulation of the PRRX2 Gene
Hiroki Ueharu et al.
JOURNAL OF REPRODUCTION AND DEVELOPMENT (2014)
Preclinical Evaluation of AMG 925, a FLT3/CDK4 Dual Kinase Inhibitor for Treating Acute Myeloid Leukemia
Kathleen Keegan et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Cyclin-Dependent Kinase 6 Is a Chromatin-Bound Cofactor for NF-κB-Dependent Gene Expression
Katja Handschick et al.
MOLECULAR CELL (2014)
SOCS3, a major regulato of infection and inflammation
Bent Carow et al.
FRONTIERS IN IMMUNOLOGY (2014)
Gene methylation and silencing of SOCS3 in mantle cell lymphoma
Ommoleila Molavi et al.
BRITISH JOURNAL OF HAEMATOLOGY (2013)
A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis
Karoline Kollmann et al.
CANCER CELL (2013)
The Kinase-Independent, Second Life of CDK6 in Transcription
Tobias Otto et al.
CANCER CELL (2013)
Molecular dynamics simulations and statistical coupling analysis reveal functional coevolution network of oncogenic mutations in the CDKN2A-CDK6 complex
Jingwen Wang et al.
FEBS LETTERS (2013)
Pim-1 Kinase Phosphorylates and Stabilizes 130 kDa FLT3 and Promotes Aberrant STAT5 Signaling in Acute Myeloid Leukemia with FLT3 Internal Tandem Duplication
Karthika Natarajan et al.
PLOS ONE (2013)
CDK6 and p16INK4A in lymphoid malignancies
Karoline Kollmann et al.
ONCOTARGET (2013)
Breakpoint Analysis of Transcriptional and Genomic Profiles Uncovers Novel Gene Fusions Spanning Multiple Human Cancer Types
Craig P. Giacomini et al.
PLOS GENETICS (2013)
Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia
Satomi Tanaka et al.
BLOOD (2012)
Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma
John P. Leonard et al.
BLOOD (2012)
Incidence, survival and prevalence of myeloid malignancies in Europe
O. Visser et al.
EUROPEAN JOURNAL OF CANCER (2012)
ETV6 rearrangements are recurrent in myeloid malignancies and are frequently associated with other genetic events
Claudia Haferlach et al.
GENES CHROMOSOMES & CANCER (2012)
A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells
Lars Anders et al.
CANCER CELL (2011)
IL-6 Controls Leukemic Multipotent Progenitor Cell Fate and Contributes to Chronic Myelogenous Leukemia Development
Damien Reynaud et al.
CANCER CELL (2011)
The PPE18 Protein of Mycobacterium tuberculosis Inhibits NF-κB/rel-Mediated Proinflammatory Cytokine Production by Upregulating and Phosphorylating Suppressor of Cytokine Signaling 3 Protein
Shiny Nair et al.
JOURNAL OF IMMUNOLOGY (2011)
Sprouty1 Regulates Reversible Quiescence of a Self-Renewing Adult Muscle Stem Cell Pool during Regeneration
Kelly L. Shea et al.
CELL STEM CELL (2010)
The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells
Olga Sirin et al.
NATURE CELL BIOLOGY (2010)
Clinicopathologic Features of CDK6 Translocation-associated B-cell Lymphoproliferative Disorders
Dong Chen et al.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2009)
JunB Protects against Myeloid Malignancies by Limiting Hematopoietic Stem Cell Proliferation and Differentiation without Affecting Self-Renewal
Marianne Santaguida et al.
CANCER CELL (2009)
Src family kinase gene targets during myeloid differentiation: identification of the EGR-1 gene as a direct target
J. E. Jones et al.
LEUKEMIA (2009)
Chromosome 14q32 translocations involving the immunoglobulin heavy chain locus in chronic lymphocytic leukaemia identify a disease subset with poor prognosis
Francesco Cavazzini et al.
BRITISH JOURNAL OF HAEMATOLOGY (2008)
H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias
Andrei V. Krivtsov et al.
CANCER CELL (2008)
Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair
Anne Wilson et al.
CELL (2008)
The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells
Irene M. Min et al.
CELL STEM CELL (2008)
KLF6 Induces Apoptosis in Prostate Cancer Cells through Up-regulation of ATF3
Xiangwei Huang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Leukemia suppressor function of Egr-1 is dependent on transforming oncogene
J. D. Gibbs et al.
LEUKEMIA (2008)
Amplification at 7q22 targets cyclin-dependent kinase 6 in T-cell lymphoma
S. Nagel et al.
LEUKEMIA (2008)
Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia
Lisheng Wang et al.
BLOOD (2007)
Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders
John M. Joslin et al.
BLOOD (2007)
Suppressor of cytokine signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex
Helle Frobose et al.
MOLECULAR ENDOCRINOLOGY (2006)
Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development
Ruth Schwartz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Kruppel-Like Factor 4 Regulates Proliferation of Human and Mouse Hematopoietic Stem-Progenitor Cells, but Is Not Essential for Mouse Hematopoietic Repopulation
Jonathan K. Alder et al.
MOLECULAR THERAPY (2006)
The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation
CHM Jamieson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Egr-1 abrogrates the block imparted by c-Myc on terminal M1 myeloid differentiation
M Shafarenko et al.
BLOOD (2005)
A gain-of-function mutation of JAK2 in myeloproliferative disorders
R Kralovics et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
RL Levine et al.
CANCER CELL (2005)
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
EJ Baxter et al.
LANCET (2005)
Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexes
K Kozar et al.
CELL CYCLE (2005)
AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia:: Implication in stepwise leukemogenesis and response to Gleevec
YY Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Mammalian cells cycle without the D-type cyclin-elependent kinases Cdk4 and Cdk6
M Malumbres et al.
CELL (2004)
Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia
XY Su et al.
GENES CHROMOSOMES & CANCER (2004)
Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1
S Benzeno et al.
CANCER RESEARCH (2004)
InB-cell chronic lymphocytic leukemias, 7q21 translocations lead to overexpression of the CDK6 gene
S Hayette et al.
BLOOD (2003)
Disruption of differentiation in human cancer: AML shows the way
DG Tenen
NATURE REVIEWS CANCER (2003)
Expression of cyclin-dependent kinase 6 (cdk6) and frequent loss of CD44 in nasal-nasopharyngeal NK/T-Cell lymphomas: Comparison with CD56-negative peripheral T-cell lymphomas
HC Lien et al.
LABORATORY INVESTIGATION (2000)
Nora, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
E Oda et al.
SCIENCE (2000)