Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/ijms21082972
Keywords
colorectal cancer; murine model; inflammation; Aberrant Crypt Foci
Funding
- Italian Ministry of Health [GR-2011-02347991, GR-2009-1470633]
- PO FESR 2014-2020-Piattaforme tecnologiche di ricerca collaborativa per la lotta alle patologie oncologiche
- SiCURA Soluzioni Innovative per la gestione del paziente e il follow up terapeutico della Colite UlceRosA
- Ricerca Corrente 2019 IRCCS S. de Bellis
- PON -Ricerca e Innovazione 2014-2020 [AIM1801289]
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(1) Background: Colorectal cancer (CRC) is among the best examples of the relationship between inflammation and increased cancer risk. (2) Methods: To examine the effects of spontaneous low-grade chronic inflammation on the pathogenesis of CRC, we developed a new murine model of colitis-associated cancer (CAC) by crossing Mucin 2 mutated mice (Winnie) with Apc(Min/+) mice. (3) Results: The resulting Winnie-Apc(Min/+) model combines an inflammatory background with a genetic predisposition to small intestinal polyposis. Winnie-Apc(Min/+) mice show an early occurrence of inflammatory signs and dysplastic lesions in the distal colon with a specific molecular signature. (4) Conclusion: The Winnie-Apc(Min/+) model is a perfect model to demonstrate that chronic inflammation represents a crucial risk factor for the onset and progression of tumoral lesions in individuals genetically predisposed to CRC.
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