Journal
CEREBRAL CORTEX
Volume 27, Issue 9, Pages 4492-4502Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhw253
Keywords
functional connectivity; head motion; IQ; movement; resting state
Categories
Funding
- National Institute of Child Health and Human Development [U54 HD087011, 5R01HD061117]
- American Heart Association [14PRE19610010]
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A growing field of research explores links between behavioral measures and functional connectivity (FC) assessed using resting-state functional magnetic resonance imaging. Recent studies suggest that measurement of these relationships may be corrupted by head motion artifact. Using data from the Human Connectome Project (HCP), we find that a surprising number of behavioral, demographic, and physiological measures (23 of 122), including fluid intelligence, reading ability, weight, and psychiatric diagnostic scales, correlate with head motion. We demonstrate that trait (across-subject) and state (across-day, within-subject) effects of motion on FC are remarkably similar in HCP data, suggesting that state effects of motion could potentially mimic trait correlates of behavior. Thus, head motion is a likely source of systematic errors (bias) in the measurement of FC: behavior relationships. Next, we show that data cleaning strategies reduce the influence of head motion and substantially alter previously reported FC: behavior relationship. Our results suggest that spurious relationships mediated by head motion may be widespread in studies linking FC to behavior.
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