Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 150, Issue -, Pages 559-572Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.02.097
Keywords
Polysaccharides; In situ gel; Ocular drug delivery; Sustained release; Bioavailability; Nanoformulation
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The major complications associated with the administration of ocular dosage forms are the precorneal loss due to the nasolacrimal drainage and high turnover of tear fluid. In situ forming gels are developed to overcome these complications. In situ gelling systems are polymeric solutions converted into a viscoelastic gel in the ocular surface due to a change in temperature, ionic strength, and p(H). Recently, the use of responsive polysaccharides containing in situ gel formulation has increased due to its biocompatible nature, non-toxicity, and biodegradability. The research on in situ gel using polysaccharide in the delivery of drug molecules through the ocular route has diversified in various fields. However, there is no report are available that summaries this progress. The aim of this article is to bridge that lacuna. We discuss different polysaccharides based in situ gel including pH, temperature, ion and multiple sensitive used in ocular drug delivery. The nanoformulation incorporated polysaccharide in situ gels for ocular drug delivery has also been highlighted. (C) 2020 Elsevier B.V. All rights reserved.
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