Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 150, Issue -, Pages 189-199Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.02.031
Keywords
Tara gum; Galactomannans; Sulfation
Funding
- National Science Foundation of China [21204073, 51463022]
- Science Fund for Distinguished Young Scholars of Gansu Province [17JR5RA067]
- Science and Technology Innovation Special Fund Project of Gansu Province, China [2019ZX-05]
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Interest in galactomannans and its derivatives as a functional health supplement is growing based on physicochemical properties. In this work, the optimized conditions of sulfated tara gum (STG) with a maximum DS of 0.66 by box-behnken design (BBD) were obtained as following: ratio of chlorosulfonic acid/pyridine 3:1, reaction time 4 h and reaction temperature 40 degrees C. The structure features of STG such as the degree of substitution (DS), substitution position, weight average molar mass (MW), monosaccharide components and chain conformation were investigated. Decreasing of MW, the increasing of Z-average radius of gyration (< S-2 >(1/2)(Z)) and specific volume for gyration (SVg) were obtained by SEC-MALLS. In addition, the structural properties of four sulfated galactomannans were comparatively investigated and analyzed based on our earlier reports of sulfated fenugreek gum, guar gum and locust bean gum. A conclusion was drown that higher galactose branch could enhance steric hindrance, which was inferred as one of the significant factors for the derivatization efficiency, thus affecting the DS, MW and conformational transition of sulfated galactomannans. This study will provide valuable information for further research on the comparison of bioactivities and medical application of galactomannans family. (c) 2020 Elsevier B.V. All rights reserved.
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