Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 82, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2020.106295
Keywords
PD-1; Tfh cell; Non-small cell lung cancer
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PD-1 inhibitors have been used to revive exhausted T cell responses in non-small cell lung cancer (NSCLC) and other malignancies. CXCR5(+) T follicular helper (Tfh) cells are characterized by constitutive high PD-1 expression and have been associated with the formation of tertiary lymphoid structures and implicated in anti-tumor immunity. In this study, we investigated the effect of PD-1 and PD-1 inhibition on CXCR5(+) CD4 T cells. Data showed that CXCR5(+) CD4 T cells in both healthy subjects and NSCLC patients presented markedly higher PD-1 expression than CXCR5(-) CD4 T cells. Both CXCR5(-) and CXCR5(+) CD4 T cells from NSCLC patients presented higher PD-1 expression than their counterparts in healthy subjects. PD-1(+) CXCR5(+) CD4 T cells were functional, could express IL-21, IL-10, and CXCL13 upon stimulation, demonstrated auxiliary effects toward CD8 T cell-mediated IFN-gamma production and proliferation, and promoted IgM and IgG production. However, the potency of PD-1(+) CXCR5(+) CD4 T cells was lower than the potency of PD-1 CXCR5(+) CD4 T cells. PD-1 blocking could significantly enhance the effector functions of PD-1(+ )CXCR5(+) CD4 T cells. Overall, this study demonstrated that PD-1(+ )CXCR5(+) CD4 T cells could promote CD8 T cell and B cell inflammation and could be modulated by PD-1 inhibition.
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