Journal
INTERNAL MEDICINE
Volume 59, Issue 6, Pages 805-809Publisher
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.3306-19
Keywords
variant hemoglobin; Hb Phnom Penh; HbA1c; high performance liquid chromatography
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We herein report a 50-year-old Chinese woman with Hb Phnom Penh (alpha 117Phe-Ile-alpha 118Thr) showing high or reasonable HbA1c values depending on the type of high-performance liquid chromatography (HPLC) system. A high HbA1c value of 7.5% (HPLC assay: G9) and a reasonable HbA1c value of 5.2% (assay unknown) were observed. Therefore, the patient was refereed to our hospital; the oral glucose tolerance test showed normal glucose tolerance. The HbA1c values measured by an enzymatic assay, immunoassay, and affinity assay, as well as most HPLC assays were within the reference range, whereas those measured by the Tosoh HPLC systems were high.
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