Journal
INTERNAL MEDICINE
Volume 59, Issue 8, Pages 1099-1104Publisher
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.3954-19
Keywords
Behcet's disease; herpes zoster; autonomic disorder; IL-10
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A 58-year-old Japanese woman with herpes zoster developed Behcet's disease (BD) with symptoms including orthostatic intolerance as an autonomic disorder. Multiple immune-suppressive therapies and a beta-blocker successfully controlled both the disease activity of BD and the autonomic disorders. A cytokine multiplex analysis of her serum revealed the elevation of proinflammatory cytokines [interleukin (IL)-1, IL-6, IL-12, tumor necrosis factor alfa (TNF alpha), and interferon gamma (IFN-gamma)] and a low IL-10 concentration. IL-10 production is reported to be important for defense against herpes zoster virus (VZV). Insufficient IL-10 production is reported in BD. The reactivation of VZV with this cytokine profile suggests that BD will develop with various symptoms, including severe autonomic disorders.
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