Journal
INTERNAL MEDICINE
Volume 59, Issue 8, Pages 1035-1040Publisher
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.4072-19
Keywords
hepatitis-associated aplastic anemia; liver fibrosis
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Hepatitis-associated aplastic anemia (HAAA) is a variant of acquired aplastic anemia and characterized by bone marrow failure that follows the development of acute hepatitis. We herein report a rare case of HAAA with rapid progression of liver fibrosis due to repeated hepatitis. A pathological examination of liver specimens revealed liver fibrosis progression over a short period. Immunosuppressive therapy with cyclosporine effectively cured both the pancytopenia and hepatitis. Our case suggests that the pathological examination of the liver tissue is useful for determining a treatment plan and that immunosuppressive therapy is a promising treatment for both aplastic anemia and persistent hepatitis.
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