Journal
INORGANICA CHIMICA ACTA
Volume 504, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2020.119450
Keywords
Copper(II); Nalidixic acid; Bis-ethylenediamine complex; DNA docking; Oxidative DNA cleavage; Cytotoxicity
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Funding
- Science and Engineering Research Board (SERB), New Delhi [EMR/2015/002222]
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The new complexes [Cu(nal)(2)]center dot 2H(2)O 1 and [Cu(en)(2)(nal)(2)] 2, where H(nal) is the antibacterial drug nalidixic acid, have been isolated and their X-ray structures successfully determined. The complex 1 possesses a square planar CuO4 chromophore constituted by the pyridone and carboxylate oxygen atoms of nalidixate anion. Complex 2 contains a CuN4O2 chromophore with a tetragonally distorted octahedral geometry, and the transaxial coordination of two nalidixate anions at longer distances to the CuN4 plane constituted by ethylenediamine is stabilized by a network of H-bonding. DFT studies illustrate the structures and stabilities of complexes. The DNA binding affinity of 2 (K-b, 9.2 (+/- 0.2) x 10(4) M-1) is higher than that of [Cu(en)(2)](2+) [K-b, 2.0 (+/- 0.2) x 10(4) M-1], illustrating that bound nal(-) enhances the DNA binding affinity. DNA docking studies reveal that 2 bound to DNA undergoes interesting coordinative distortions more than 1, causing more significant changes in DNA host. Thus, 2 displays oxidative DNA cleavage (ascorbic acid) more prominent than [Cu (en)(2)](2+), by generating (OH)-O-center dot radicals, and shows poor cytotoxicity towards A549 lung cancer cell lines.
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