Journal
IMMUNOBIOLOGY
Volume 225, Issue 3, Pages -Publisher
ELSEVIER GMBH
DOI: 10.1016/j.imbio.2020.151936
Keywords
Immunomodulatory effects; Host defence peptides; Milk-derived peptides; Mammalians; Drug development
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Funding
- National Natural Science Foundation of China [81701491, 81600908]
- Natural Science Foundation of Jiangsu Province, China [BK20170152, BK20181089]
- Science and Technology Development Foundation of Nanjing Medical University [2017NJMU017]
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Modulation of immune responses by immunoregulatory agents, such as the natural or synthetic immunomodulatory peptides, has been suggested as a potential strategy to modulate immune system against infection and other immune-related diseases. These compositionally simple peptides have attracted much attention for many drug developers, due to their high activity, low toxicity and clear target specificity. Host defence peptides and milk-derived peptides are two kinds of natural immunomodulatory peptides which have been widely studied in mammalians. They could participate at the interface of innate and adaptive immunity by regulating immune effector cells. This review summarizes the recent advances in host defence peptides and milk-derived peptides as well as their general characteristics, immunomodulatory functions and possible applications.
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