Journal
IMMUNITY
Volume 52, Issue 5, Pages 724-726Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2020.04.019
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Exposure to chronic infection or malignant tumors triggers the differentiation of functionally impaired, so-called exhausted T cells. In this issue of Immunity, Beltra et al. reveal a multi-step developmental process that defines how T cells transition from proliferating progenitors into terminally differentiated exhausted T cells.
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