Journal
BIOTECHNOLOGY LETTERS
Volume 37, Issue 11, Pages 2139-2145Publisher
SPRINGER
DOI: 10.1007/s10529-015-1907-0
Keywords
Collagen; Composite materials; Drug delivery; Gelatin; Regenerative medicine; Tissue engineering
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Funding
- Macao Scientific and Technology Development Fund (FDCT) [116/2012/A]
- University of Macau Research Grants [MYRG2014-00069-ICMS-QRCM, MRG018/WCM/2013/ICMS]
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The biomacromolecule, gelatin, has increasingly been used in biomedicine-beyond its traditional use in food and cosmetics. The appealing advantages of gelatin, such as its cell-adhesive structure, low cost, off-the-shelf availability, high biocompatibility, biodegradability and low immunogenicity, among others, have made it a desirable candidate for the development of biomaterials for tissue engineering and drug delivery. Gelatin can be formulated in the form of nanoparticles, employed as size-controllable porogen, adopted as surface coating agent and mixed with synthetic or natural biopolymers forming composite scaffolds. In this article, we review recent advances in the versatile applications of gelatin within biomedical context and attempt to draw upon its advantages and potential challenges.
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