Journal
HYPERTENSION IN PREGNANCY
Volume 39, Issue 2, Pages 165-171Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10641955.2020.1749848
Keywords
Preeclampsia; ERAP1; pathogenesi
Funding
- Health and Family Planning Commission of Fujian [2016-ZQN-46]
Ask authors/readers for more resources
Objective: This study aimed to investigate the expression and role of ERAP1 in preeclampsia pathogenesis. Methods: ERAP1 expression of placental tissues was analyzed by Real-Time PCR and western blot. The location of ERAP1 was detected by immunohistochemistry. Cellular preeclampsia model was established by hypoxia treatment of HTR-8/SVneo cells (2% oxygen). Results: The present study revealed that ERAP1 expression were significantly elevated in placental tissues of preeclampsia, and hypoxiaincreased ERAP1 expression in trophoblast, suggesting that ERAP-1 may be involved in the development of preeclampsia. Conclusion: These finds highlight the role of ERAP1 in the pathogenesis of preeclampsia.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available