Journal
HUMAN BRAIN MAPPING
Volume 43, Issue 1, Pages 341-351Publisher
WILEY
DOI: 10.1002/hbm.24988
Keywords
amygdala; ENIGMA; hippocampus; major depressive disorder (MDD); nucleus accumbens; shape analysis
Funding
- National Health and Medical Research Council [1140764]
- National Institute of Aging [R01AG059874, R56AG058854, T32AG058507]
- National Institute of Biomedical Imaging and Bioengineering [P41EB015922, U54EB020403]
- National Institute of Mental Health [K01MH117442, R01MH117601, R01MH111671, R01MH116147, T32MH073526, R37MH101495]
- Biogen, Inc.
- Roche Pharmaceuticals
- Servier Pharmaceuticals
- Fresenius Medical Care
- Janssen Cilag
- Max Planck Institute of Psychiatry, Munich
- European Social Fund (ESF)
- EU Joint Programme Neurodegenerative Disorders (JPND)
- DAMP Foundation
- German Ministry of Education and Research (BMBF)
- Lundbeck
- Gratama Foundation [2012/35]
- Interdisciplinary Center for Clinical Research (IZKF) of the Medical Faculty of Munster [Dan3/012/17]
- German Research Foundation [SA 1358/2-1, DFG-SFB779/TPA06, SCHR443/11-1, SCHN 1205/3-1, WA 1539/4-1, FOR2107 JA 1890/7-2, FOR2107 NE 2254/1-2, FOR2107 KI 588/14-2, FOR2107 KR 3822/7-2, SFB-TRR58, DA1151/5-2, FOR2107 DA1151/5-1]
- Federal State of Mecklenburg-West Pomerania
- Siemens Healthineers
- German Federal State of Mecklenburg-West Pomerania
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This study investigated the differences in subcortical shape between patients with major depressive disorder (MDD) and healthy controls. The results showed that both adolescent-onset MDD and recurrent MDD patients had lower thickness and surface area in certain subcortical regions compared to healthy controls.
Alterations in regional subcortical brain volumes have been investigated as part of the efforts of an international consortium, ENIGMA, to identify reliable neural correlates of major depressive disorder (MDD). Given that subcortical structures are comprised of distinct subfields, we sought to build significantly from prior work by precisely mapping localized MDD-related differences in subcortical regions using shape analysis. In this meta-analysis of subcortical shape from the ENIGMA-MDD working group, we compared 1,781 patients with MDD and 2,953 healthy controls (CTL) on individual measures of shape metrics (thickness and surface area) on the surface of seven bilateral subcortical structures: nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, and thalamus. Harmonized data processing and statistical analyses were conducted locally at each site, and findings were aggregated by meta-analysis. Relative to CTL, patients with adolescent-onset MDD (<= 21 years) had lower thickness and surface area of the subiculum, cornu ammonis (CA) 1 of the hippocampus and basolateral amygdala (Cohen's d = -0.164 to -0.180). Relative to first-episode MDD, recurrent MDD patients had lower thickness and surface area in the CA1 of the hippocampus and the basolateral amygdala (Cohen's d = -0.173 to -0.184). Our results suggest that previously reported MDD-associated volumetric differences may be localized to specific subfields of these structures that have been shown to be sensitive to the effects of stress, with important implications for mapping treatments to patients based on specific neural targets and key clinical features.
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