Journal
HUMAN BRAIN MAPPING
Volume 43, Issue 1, Pages 37-55Publisher
WILEY
DOI: 10.1002/hbm.25029
Keywords
ADHD; ASD; cortex; ENIGMA; neuroimaging; subcortical volumes
Funding
- personal Veni grant of the Netherlands Organization for Scientific Research (NWO) [91619115]
- personal VIDI grant of the Netherlands Organization for Scientific Research (NWO/ZonMw) [91717306]
- NIH [R01MH62873, R01 MH115357]
- NWO [1750102007010, 056-13-015, 433-09-242]
- ZonMW [60-60600-97-193]
- Radboud University Nijmegen Medical Center
- University Medical Center Groningen
- Vrije Universiteit Amsterdam
- European Community [278948, 602805, 603016, 602450]
- Innovation Medicine Initiative grants [115300, 777394]
- Dutch National Science Agenda [400 17 602]
- Biobanking and Biomolecular Resources Research Infrastructure (Netherlands) (BBMRI-NL)
- Hersenstichting Nederland
- Netherlands Organization for Scientific Research (NWO)
- BD2K Initiative of a cross-NIH partnership [U54 EB020403]
- Ontario Brain Institute [IDS-I l-02]
- CIHR [CIHR-106582, CIHR-142379]
- U.S. National Institutes of Health Big Data to Knowledge Program (BD2K) [U54 EB020403]
- University Medical Center Accare
- MRC [G0300189] Funding Source: UKRI
Ask authors/readers for more resources
Neuroimaging has been extensively used to study brain structure and function in individuals with ADHD and ASD. However, there have been limitations in the current literature, such as small sample sizes and heterogeneous methods. To address these limitations, the ENIGMA-ADHD and ENIGMA-ASD working groups were established to collaborate on large-scale neuroimaging projects. The findings so far have shown overlap and unique differences in cortical structures between ASD and ADHD. Ongoing work is exploring other research questions.
Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA-ADHD and ENIGMA-ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA-ADHD and -ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case-control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case-control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow-up analyses continue that include more imaging modalities (diffusion MRI and resting-state functional MRI), collaborations with other large databases, and samples with dual diagnoses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available