Journal
HORMONE AND METABOLIC RESEARCH
Volume 52, Issue 6, Pages 379-385Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1120-8647
Keywords
primary aldosteronism; angiotensin II receptor; autoantibodies; endocrine hypertension; adrenal cortex
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Funding
- European Research Council (ERC) under the European Union [694913]
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [314061271-TRR 205]
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Primary aldosteronism (PA) is the most common form of endocrine hypertension. Agonistic autoantibodies against the angiotensin II type 1 receptor (AT(1)R-Abs) have been described in transplantation medicine and women with pre-eclampsia and more recently in patients with PA. Any functional role of AT(1)R-Abs in either of the two main subtypes of PA (aldosterone-producing adenoma or bilateral adrenal hyperplasia) requires clarification. In this review, we discuss the studies performed to date on AT(1)R-Abs in PA.
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