Journal
GENE THERAPY
Volume 27, Issue 7-8, Pages 329-337Publisher
SPRINGERNATURE
DOI: 10.1038/s41434-020-0155-7
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [81970878, 31771130]
- Shanghai Municipal Government
- ShanghaiTech University
Ask authors/readers for more resources
Gene therapy for auditory diseases is gradually maturing. Recent progress in gene therapy treatments for genetic and acquired hearing loss has demonstrated the feasibility in animal models. However, a number of hurdles, such as lack of safe viral vector with high efficiency and specificity, robust deafness large animal models, translating animal studies to clinic etc., still remain to be solved. It is necessary to overcome these challenges in order to effectively recover auditory function in human patients. Here, we review the progress made in our group, especially our efforts to make more effective and cell type-specific viral vectors for targeting cochlea cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available