Journal
CEPHALALGIA
Volume 37, Issue 10, Pages 955-964Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0333102416663459
Keywords
Migraine; adherence; disability; acute drug therapy; patient satisfaction
Categories
Funding
- NINDS [NS048288, 1K23NS096107-01]
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Objective: To examine the influence of acute migraine medication adherence on migraine disability and acute medication satisfaction. Methods: Adults with migraine completed three months of daily electronic diaries assessing headache symptoms, acute medication taken, acute medication satisfaction, and daily migraine disability. Repeated measures mixed-effects models examined the effect of initial medication type [migraine-specific medication (MSM) vs. over-the-counter analgesic (OTC) vs. an opiate/barbiturate], the severity of pain at dosing, and their interaction with daily migraine disability and satisfaction with acute medication. Results: Participants (N = 337; 92.5% female; 91.1% Caucasian, non-Hispanic; 84.0% with episodic migraine) recorded 29,722 diary days. Participants took acute medication on 96.5% of 8090 migraine days. MSM was most frequently taken first (58%), followed by OTC (29.9%) and an opiate/barbiturate (12.1%). Acute medication was most frequently taken when pain was mild (41.2%), followed by moderate (37.7%) and severe pain (11.4%). Initially dosing with MSM while pain was mild was associated with the lowest daily disability [medication x pain at dosing F (4, 6336.12) = 58.73, p<. 001] and highest acute medication satisfaction [medication x pain at dosing F (4, 3867.36) = 24.00, p<. 001]. Conclusion: Using an MSM (triptan or ergot) first was associated with the lowest migraine disability and highest acute medication satisfaction.
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