Journal
FOOD SCIENCE AND BIOTECHNOLOGY
Volume 29, Issue 7, Pages 997-1005Publisher
KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
DOI: 10.1007/s10068-020-00739-1
Keywords
Urushiol; 3-pentadecylcatechol; Rhus vernicifluaStokes; Absorption metabolism
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Urushiols are important active compounds found in the sap of the lacquer tree (Rhus vernicifluaStokes). Recently, various biological effects of urushiols, such as antioxidant, antimicrobial, and anticancer activities, have been reported. However, urushiols can also induce skin allergies. Nevertheless, the lacquer tree has traditionally been used in Korea as a folk medicine. In this study, we evaluated the absorption and metabolism of 3-pentadecylcatechol (PDC), a natural urushiol. PDC (48.0 mg/kg body wt.) in 1 mL propylene glycol was orally administered to rats (Sprague-Dawley, male, 6 weeks old). Blood plasma, urine, and feces were collected, separately. PDC was not detected in the extracts from rat blood plasma and urine. However, 89.4 +/- 5.2% of the orally administered PDC was detected in the feces extracts, indicating that PDC was predominantly excreted and not absorbed.
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