Journal
FITOTERAPIA
Volume 142, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2020.104490
Keywords
Diarylheptanoids; Privileged scaffold; Natural products; Chemical components; Bioactivities
Categories
Funding
- National Natural Science Foundation of China [81602627, 81602953, 81603275]
- Liaoning Province Natural Science Foundation [2019-MS-299]
- Liaoning Revitalization Talents Program [XLYC1807182]
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Privileged structures are widely used in the process of drug design, and provide an effective template in medicinal chemistry. Diarylheptanoids are a class of structurally distinctive compounds with a wide variety of bioactivity, raising keenly interest in the past decades. Turmeric is a golden spice from the rhizome of the plant Curcuma longa, used for food preparations and giving color since ancient times. Curcumin, obtained from turmeric, has showed widely biological abilities with low toxicity in recent studied. Thus, a spice originally common in the kitchen has recently broadened its application to the clinic. This review aims to highlight diarylheptanoid as a privileged scaffold in drug discovery. In this review, we summarized diverse biological and pharmacological effects of diarylheptanoids and explored the therapeutic application and development of diet based on their structure.
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